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Vascular dementia

MedGen UID:
41447
•Concept ID:
C0011269
•
Disease or Syndrome
Synonyms: Dementia, Vascular; Dementias, Vascular; Vascular Dementia; Vascular Dementias
SNOMED CT: Vascular dementia (429998004)
 
Monarch Initiative: MONDO:0004648

Definition

A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions. [from NCI]

Professional guidelines

PubMed

Dementia Prevention and Treatment: A Narrative Review.
Reuben DB, Kremen S, Maust DT
JAMA Intern Med 2024 May 1;184(5):563-572. doi: 10.1001/jamainternmed.2023.8522. PMID: 38436963
Cognitive Impairment in Older Adults: Epidemiology, Diagnosis, and Treatment.
Pérez Palmer N, Trejo Ortega B, Joshi P
Psychiatr Clin North Am 2022 Dec;45(4):639-661. Epub 2022 Oct 14 doi: 10.1016/j.psc.2022.07.010. PMID: 36396270
Cannabinoids for the treatment of dementia.
Bosnjak Kuharic D, Markovic D, Brkovic T, Jeric Kegalj M, Rubic Z, Vuica Vukasovic A, Jeroncic A, Puljak L
Cochrane Database Syst Rev 2021 Sep 17;9(9):CD012820. doi: 10.1002/14651858.CD012820.pub2. PMID: 34532852Free PMC Article

Recent clinical studies

Etiology

Vascular Cognitive Impairment and Dementia.
Chang Wong E, Chang Chui H
Continuum (Minneap Minn) 2022 Jun 1;28(3):750-780. doi: 10.1212/CON.0000000000001124. PMID: 35678401Free PMC Article
Inflammation, apoptosis and autophagy as critical players in vascular dementia.
Wang XX, Zhang B, Xia R, Jia QY
Eur Rev Med Pharmacol Sci 2020 Sep;24(18):9601-9614. doi: 10.26355/eurrev_202009_23048. PMID: 33015803
Behavioral and psychological symptoms in Alzheimer's dementia and vascular dementia.
Deardorff WJ, Grossberg GT
Handb Clin Neurol 2019;165:5-32. doi: 10.1016/B978-0-444-64012-3.00002-2. PMID: 31727229
Epidemiology of Vascular Dementia.
Wolters FJ, Ikram MA
Arterioscler Thromb Vasc Biol 2019 Aug;39(8):1542-1549. Epub 2019 Jul 11 doi: 10.1161/ATVBAHA.119.311908. PMID: 31294622
Vascular dementia.
O'Brien JT, Thomas A
Lancet 2015 Oct 24;386(10004):1698-706. doi: 10.1016/S0140-6736(15)00463-8. PMID: 26595643

Diagnosis

Vascular Cognitive Impairment and Dementia.
Chang Wong E, Chang Chui H
Continuum (Minneap Minn) 2022 Jun 1;28(3):750-780. doi: 10.1212/CON.0000000000001124. PMID: 35678401Free PMC Article
Behavioral and psychological symptoms in Alzheimer's dementia and vascular dementia.
Deardorff WJ, Grossberg GT
Handb Clin Neurol 2019;165:5-32. doi: 10.1016/B978-0-444-64012-3.00002-2. PMID: 31727229
Magnetic resonance imaging in dementia.
Raposo Rodríguez L, Tovar Salazar DJ, Fernández García N, Pastor Hernández L, Fernández Guinea Ó
Radiologia (Engl Ed) 2018 Nov-Dec;60(6):476-484. Epub 2018 Jun 11 doi: 10.1016/j.rx.2018.04.003. PMID: 29903629
The pathology and pathophysiology of vascular dementia.
Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521
Vascular dementia.
O'Brien JT, Thomas A
Lancet 2015 Oct 24;386(10004):1698-706. doi: 10.1016/S0140-6736(15)00463-8. PMID: 26595643

Therapy

Pharmacological Management of Apathy in Dementia.
Azhar L, Kusumo RW, Marotta G, Lanctôt KL, Herrmann N
CNS Drugs 2022 Feb;36(2):143-165. Epub 2022 Jan 10 doi: 10.1007/s40263-021-00883-0. PMID: 35006557
Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia.
Mühlbauer V, Möhler R, Dichter MN, Zuidema SU, Köpke S, Luijendijk HJ
Cochrane Database Syst Rev 2021 Dec 17;12(12):CD013304. doi: 10.1002/14651858.CD013304.pub2. PMID: 34918337Free PMC Article
Neuroimaging in Dementias.
Mahalingam S, Chen MK
Semin Neurol 2019 Apr;39(2):188-199. Epub 2019 Mar 29 doi: 10.1055/s-0039-1678580. PMID: 30925612
Cadasil.
Chabriat H, Joutel A, Dichgans M, Tournier-Lasserve E, Bousser MG
Lancet Neurol 2009 Jul;8(7):643-53. doi: 10.1016/S1474-4422(09)70127-9. PMID: 19539236
Ginkgo biloba.
Sierpina VS, Wollschlaeger B, Blumenthal M
Am Fam Physician 2003 Sep 1;68(5):923-6. PMID: 13678141

Prognosis

The Association Between Eye Disease and Incidence of Dementia: Systematic Review and Meta-Analysis.
Feng J, Huang C, Liang L, Li C, Wang X, Ma J, Guan X, Jiang B, Huang S, Qin P
J Am Med Dir Assoc 2023 Sep;24(9):1363-1373.e6. Epub 2023 Jul 29 doi: 10.1016/j.jamda.2023.06.025. PMID: 37527793
Handgrip strength and all-cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study.
Esteban-Cornejo I, Ho FK, Petermann-Rocha F, Lyall DM, Martinez-Gomez D, Cabanas-Sánchez V, Ortega FB, Hillman CH, Gill JMR, Quinn TJ, Sattar N, Pell JP, Gray SR, Celis-Morales C
J Cachexia Sarcopenia Muscle 2022 Jun;13(3):1514-1525. Epub 2022 Apr 21 doi: 10.1002/jcsm.12857. PMID: 35445560Free PMC Article
The Alzheimer's Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease: JACC Focus Seminar.
Stakos DA, Stamatelopoulos K, Bampatsias D, Sachse M, Zormpas E, Vlachogiannis NI, Tual-Chalot S, Stellos K
J Am Coll Cardiol 2020 Mar 3;75(8):952-967. doi: 10.1016/j.jacc.2019.12.033. PMID: 32130931Free PMC Article
Maternal Stroke: an Update.
Zambrano MD, Miller EC
Curr Atheroscler Rep 2019 Jun 22;21(9):33. doi: 10.1007/s11883-019-0798-2. PMID: 31230137Free PMC Article
MIND not Mediterranean diet related to 12-year incidence of cognitive impairment in an Australian longitudinal cohort study.
Hosking DE, Eramudugolla R, Cherbuin N, Anstey KJ
Alzheimers Dement 2019 Apr;15(4):581-589. Epub 2019 Feb 28 doi: 10.1016/j.jalz.2018.12.011. PMID: 30826160

Clinical prediction guides

Iron and risk of dementia: Mendelian randomisation analysis in UK Biobank.
Casanova F, Tian Q, Atkins JL, Wood AR, Williamson D, Qian Y, Zweibaum D, Ding J, Melzer D, Ferrucci L, Pilling LC
J Med Genet 2024 Apr 19;61(5):435-442. doi: 10.1136/jmg-2023-109295. PMID: 38191510Free PMC Article
"Life's Essential 8" Cardiovascular Health and Dementia Risk, Cognition, and Neuroimaging Markers of Brain Health.
Zhou R, Chen HW, Li FR, Zhong Q, Huang YN, Wu XB
J Am Med Dir Assoc 2023 Nov;24(11):1791-1797. Epub 2023 Jun 24 doi: 10.1016/j.jamda.2023.05.023. PMID: 37369360
Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis.
Beauchet O, Annweiler C, Callisaya ML, De Cock AM, Helbostad JL, Kressig RW, Srikanth V, Steinmetz JP, Blumen HM, Verghese J, Allali G
J Am Med Dir Assoc 2016 Jun 1;17(6):482-90. Epub 2016 Feb 4 doi: 10.1016/j.jamda.2015.12.092. PMID: 26852960Free PMC Article
Diagnostic criteria of dementia.
Bouchard RW
Can J Neurol Sci 2007 Mar;34 Suppl 1:S11-8. doi: 10.1017/s0317167100005497. PMID: 17469675
Clinical diagnosis of vascular dementia.
Nagata K, Saito H, Ueno T, Sato M, Nakase T, Maeda T, Satoh Y, Komatsu H, Suzuki M, Kondoh Y
J Neurol Sci 2007 Jun 15;257(1-2):44-8. Epub 2007 Apr 19 doi: 10.1016/j.jns.2007.01.049. PMID: 17445833

Recent systematic reviews

Physical activity as a protective factor for dementia and Alzheimer's disease: systematic review, meta-analysis and quality assessment of cohort and case-control studies.
Iso-Markku P, Kujala UM, Knittle K, Polet J, Vuoksimaa E, Waller K
Br J Sports Med 2022 Jun;56(12):701-709. Epub 2022 Mar 17 doi: 10.1136/bjsports-2021-104981. PMID: 35301183Free PMC Article
Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia.
Mühlbauer V, Möhler R, Dichter MN, Zuidema SU, Köpke S, Luijendijk HJ
Cochrane Database Syst Rev 2021 Dec 17;12(12):CD013304. doi: 10.1002/14651858.CD013304.pub2. PMID: 34918337Free PMC Article
The Prevalence of Dementia: A Systematic Review and Meta-Analysis.
Cao Q, Tan CC, Xu W, Hu H, Cao XP, Dong Q, Tan L, Yu JT
J Alzheimers Dis 2020;73(3):1157-1166. doi: 10.3233/JAD-191092. PMID: 31884487
Alcohol use and dementia: a systematic scoping review.
Rehm J, Hasan OSM, Black SE, Shield KD, Schwarzinger M
Alzheimers Res Ther 2019 Jan 5;11(1):1. doi: 10.1186/s13195-018-0453-0. PMID: 30611304Free PMC Article
Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis.
Shi L, Chen SJ, Ma MY, Bao YP, Han Y, Wang YM, Shi J, Vitiello MV, Lu L
Sleep Med Rev 2018 Aug;40:4-16. Epub 2017 Jul 6 doi: 10.1016/j.smrv.2017.06.010. PMID: 28890168

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