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Vascular dementia

MedGen UID:
41447
•Concept ID:
C0011269
•
Disease or Syndrome
Synonyms: Dementia, Vascular; Dementias, Vascular; Vascular Dementia; Vascular Dementias
SNOMED CT: Vascular dementia (429998004)
 
Monarch Initiative: MONDO:0004648

Definition

A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions. [from NCI]

Professional guidelines

PubMed

Dementia Prevention and Treatment: A Narrative Review.
Reuben DB, Kremen S, Maust DT
JAMA Intern Med 2024 May 1;184(5):563-572. doi: 10.1001/jamainternmed.2023.8522. PMID: 38436963
Cognitive Impairment in Older Adults: Epidemiology, Diagnosis, and Treatment.
Pérez Palmer N, Trejo Ortega B, Joshi P
Psychiatr Clin North Am 2022 Dec;45(4):639-661. Epub 2022 Oct 14 doi: 10.1016/j.psc.2022.07.010. PMID: 36396270
Cannabinoids for the treatment of dementia.
Bosnjak Kuharic D, Markovic D, Brkovic T, Jeric Kegalj M, Rubic Z, Vuica Vukasovic A, Jeroncic A, Puljak L
Cochrane Database Syst Rev 2021 Sep 17;9(9):CD012820. doi: 10.1002/14651858.CD012820.pub2. PMID: 34532852Free PMC Article

Recent clinical studies

Etiology

Vascular Cognitive Impairment and Dementia.
Chang Wong E, Chang Chui H
Continuum (Minneap Minn) 2022 Jun 1;28(3):750-780. doi: 10.1212/CON.0000000000001124. PMID: 35678401Free PMC Article
Inflammation, apoptosis and autophagy as critical players in vascular dementia.
Wang XX, Zhang B, Xia R, Jia QY
Eur Rev Med Pharmacol Sci 2020 Sep;24(18):9601-9614. doi: 10.26355/eurrev_202009_23048. PMID: 33015803
Behavioral and psychological symptoms in Alzheimer's dementia and vascular dementia.
Deardorff WJ, Grossberg GT
Handb Clin Neurol 2019;165:5-32. doi: 10.1016/B978-0-444-64012-3.00002-2. PMID: 31727229
Epidemiology of Vascular Dementia.
Wolters FJ, Ikram MA
Arterioscler Thromb Vasc Biol 2019 Aug;39(8):1542-1549. Epub 2019 Jul 11 doi: 10.1161/ATVBAHA.119.311908. PMID: 31294622
Vascular dementia.
O'Brien JT, Thomas A
Lancet 2015 Oct 24;386(10004):1698-706. doi: 10.1016/S0140-6736(15)00463-8. PMID: 26595643

Diagnosis

Vascular Cognitive Impairment and Dementia.
Chang Wong E, Chang Chui H
Continuum (Minneap Minn) 2022 Jun 1;28(3):750-780. doi: 10.1212/CON.0000000000001124. PMID: 35678401Free PMC Article
Behavioral and psychological symptoms in Alzheimer's dementia and vascular dementia.
Deardorff WJ, Grossberg GT
Handb Clin Neurol 2019;165:5-32. doi: 10.1016/B978-0-444-64012-3.00002-2. PMID: 31727229
Magnetic resonance imaging in dementia.
Raposo Rodríguez L, Tovar Salazar DJ, Fernández García N, Pastor Hernández L, Fernández Guinea Ó
Radiologia (Engl Ed) 2018 Nov-Dec;60(6):476-484. Epub 2018 Jun 11 doi: 10.1016/j.rx.2018.04.003. PMID: 29903629
The pathology and pathophysiology of vascular dementia.
Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521
Vascular dementia.
O'Brien JT, Thomas A
Lancet 2015 Oct 24;386(10004):1698-706. doi: 10.1016/S0140-6736(15)00463-8. PMID: 26595643

Therapy

Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia.
Mühlbauer V, Möhler R, Dichter MN, Zuidema SU, Köpke S, Luijendijk HJ
Cochrane Database Syst Rev 2021 Dec 17;12(12):CD013304. doi: 10.1002/14651858.CD013304.pub2. PMID: 34918337Free PMC Article
Trial of Pimavanserin in Dementia-Related Psychosis.
Tariot PN, Cummings JL, Soto-Martin ME, Ballard C, Erten-Lyons D, Sultzer DL, Devanand DP, Weintraub D, McEvoy B, Youakim JM, Stankovic S, Foff EP
N Engl J Med 2021 Jul 22;385(4):309-319. doi: 10.1056/NEJMoa2034634. PMID: 34289275
Neuroimaging in Dementias.
Mahalingam S, Chen MK
Semin Neurol 2019 Apr;39(2):188-199. Epub 2019 Mar 29 doi: 10.1055/s-0039-1678580. PMID: 30925612
Cadasil.
Chabriat H, Joutel A, Dichgans M, Tournier-Lasserve E, Bousser MG
Lancet Neurol 2009 Jul;8(7):643-53. doi: 10.1016/S1474-4422(09)70127-9. PMID: 19539236
Ginkgo biloba.
Sierpina VS, Wollschlaeger B, Blumenthal M
Am Fam Physician 2003 Sep 1;68(5):923-6. PMID: 13678141

Prognosis

Handgrip strength and all-cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study.
Esteban-Cornejo I, Ho FK, Petermann-Rocha F, Lyall DM, Martinez-Gomez D, Cabanas-Sánchez V, Ortega FB, Hillman CH, Gill JMR, Quinn TJ, Sattar N, Pell JP, Gray SR, Celis-Morales C
J Cachexia Sarcopenia Muscle 2022 Jun;13(3):1514-1525. Epub 2022 Apr 21 doi: 10.1002/jcsm.12857. PMID: 35445560Free PMC Article
The Alzheimer's Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease: JACC Focus Seminar.
Stakos DA, Stamatelopoulos K, Bampatsias D, Sachse M, Zormpas E, Vlachogiannis NI, Tual-Chalot S, Stellos K
J Am Coll Cardiol 2020 Mar 3;75(8):952-967. doi: 10.1016/j.jacc.2019.12.033. PMID: 32130931Free PMC Article
Maternal Stroke: an Update.
Zambrano MD, Miller EC
Curr Atheroscler Rep 2019 Jun 22;21(9):33. doi: 10.1007/s11883-019-0798-2. PMID: 31230137Free PMC Article
MIND not Mediterranean diet related to 12-year incidence of cognitive impairment in an Australian longitudinal cohort study.
Hosking DE, Eramudugolla R, Cherbuin N, Anstey KJ
Alzheimers Dement 2019 Apr;15(4):581-589. Epub 2019 Feb 28 doi: 10.1016/j.jalz.2018.12.011. PMID: 30826160
Cognitive impairment and diabetes.
Dash SK
Recent Pat Endocr Metab Immune Drug Discov 2013 May;7(2):155-65. doi: 10.2174/1872214811307020009. PMID: 23489242

Clinical prediction guides

"Life's Essential 8" Cardiovascular Health and Dementia Risk, Cognition, and Neuroimaging Markers of Brain Health.
Zhou R, Chen HW, Li FR, Zhong Q, Huang YN, Wu XB
J Am Med Dir Assoc 2023 Nov;24(11):1791-1797. Epub 2023 Jun 24 doi: 10.1016/j.jamda.2023.05.023. PMID: 37369360
Prevalence and incidence of possible vascular dementia among Mexican older adults: Analysis of the Mexican Health and Aging Study.
Yeverino-Castro SG, Mejía-Arango S, Mimenza-Alvarado AJ, Cantú-Brito C, Avila-Funes JA, Aguilar-Navarro SG
PLoS One 2021;16(7):e0253856. Epub 2021 Jul 8 doi: 10.1371/journal.pone.0253856. PMID: 34237081Free PMC Article
An algorithmic approach to structural imaging in dementia.
Harper L, Barkhof F, Scheltens P, Schott JM, Fox NC
J Neurol Neurosurg Psychiatry 2014 Jun;85(6):692-8. Epub 2013 Oct 16 doi: 10.1136/jnnp-2013-306285. PMID: 24133287Free PMC Article
Methodology for measuring cerebrovascular disease burden.
Seshadri S
Int Rev Psychiatry 2006 Oct;18(5):409-22. doi: 10.1080/09540260600935413. PMID: 17085360
Elements of mobility as predictors of survival in elderly patients with dementia: findings from the Canadian Study of Health and Aging.
Koutsavlis AT, Wolfson C
Chronic Dis Can 2000;21(3):93-103. PMID: 11082345

Recent systematic reviews

Physical activity as a protective factor for dementia and Alzheimer's disease: systematic review, meta-analysis and quality assessment of cohort and case-control studies.
Iso-Markku P, Kujala UM, Knittle K, Polet J, Vuoksimaa E, Waller K
Br J Sports Med 2022 Jun;56(12):701-709. Epub 2022 Mar 17 doi: 10.1136/bjsports-2021-104981. PMID: 35301183Free PMC Article
Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia.
Mühlbauer V, Möhler R, Dichter MN, Zuidema SU, Köpke S, Luijendijk HJ
Cochrane Database Syst Rev 2021 Dec 17;12(12):CD013304. doi: 10.1002/14651858.CD013304.pub2. PMID: 34918337Free PMC Article
Cannabinoids for the treatment of dementia.
Bosnjak Kuharic D, Markovic D, Brkovic T, Jeric Kegalj M, Rubic Z, Vuica Vukasovic A, Jeroncic A, Puljak L
Cochrane Database Syst Rev 2021 Sep 17;9(9):CD012820. doi: 10.1002/14651858.CD012820.pub2. PMID: 34532852Free PMC Article
Mini-Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI).
Arevalo-Rodriguez I, Smailagic N, Roqué-Figuls M, Ciapponi A, Sanchez-Perez E, Giannakou A, Pedraza OL, Bonfill Cosp X, Cullum S
Cochrane Database Syst Rev 2021 Jul 27;7(7):CD010783. doi: 10.1002/14651858.CD010783.pub3. PMID: 34313331Free PMC Article
The Prevalence of Dementia: A Systematic Review and Meta-Analysis.
Cao Q, Tan CC, Xu W, Hu H, Cao XP, Dong Q, Tan L, Yu JT
J Alzheimers Dis 2020;73(3):1157-1166. doi: 10.3233/JAD-191092. PMID: 31884487

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